Effects of space flight exposure on cell growth,tumorigenicity and gene expression in cancer cells

It is well recognized that harsh outer space environment, consisting of microgravity and radiation, poses significant health risks for human cells. To investigate potential effects of the space environment exposure on cancer cells we examined the biological changes in Caski cells carried by the “Shen Zhou IV” spaceship. After exposure for 7 days in spaceflight, 1440 survival subclonal cell lines were established and 4 cell lines were screened. 44F10 and 17E3 were selected because of their increased cell proliferation and tumorigenesis, while 48A9 and 31F2 had slower cytological events. Experiments with cell proliferation assay, flow cytometry, soft agar assay, tumorigenesis assay and DNA microarray analysis have shown that selected cell lines presented multiple biological changes in cell morphology, cell growth, tumorigenicity and gene expression. These results suggest that space environment exposure can make significant biological impact on cancer cells and provide an entry point to find the immunological target of tumorigenesis.     

谈二外日语教学中学生跨文化交际能力的培养

长期以来,我国二外日语教学受传统的教学方式的影响,存在着不可忽视的问题,本文提出了以学生为主体的跨文化交际能力培养的解决方法。     

A combination method using evolutionary algorithms in initial orbit determination for too short arc

With the combination of two evolutionary algorithms EDA and DE, a new method of initial orbit determination for satellites based on ground-based too-short-arc is established. Compared with other algorithms, the proposed method focuses on the most densely populated region in the solution space rather than the individual with best fitness value. Both the global information and local information are well fused in the search of optimum. In the method $(a,e,M)$ are treated as variables of the optimization, and the optimization procedure is carried out as a two-stage hierarchical optimization problem which has three variables for each stage. Kernel density estimation is applied to build the probability distribution model without any assumptions of the specified distribution, accompanied by handling semi-major axis and eccentricity as a pair of dependent variables in the construction of the probability for the correlation between them in the practice. Numerical experiments with real ground-based observations show that the proposed method is applicable to too-short-arc with even 3?s, and the result of bias in several kilometers can be achieved with $5^{″}$ error added to angular measurements.     

弹体结构平方米级扇形区域脉冲外压加载技术

针对弹体外表面平方米级区域的高峰值、短脉宽压力加载难题,依据一维可压缩流设计了高压腔、膜片腔、试验腔的气腔加载系统,附加了与试验件随形、扩展加压面积、均化压力分布的水腔,实现了平方米级区域1 MPa峰值、10 ms上升沿的脉冲压力加载要求,建立了弹性水腔的两自由度压力分析模型,获得了水腔系统的动特性参数,计算拟合曲线与...     

大比例主梁节段模型涡激振动风洞试验分析

节段模型风洞试验是预估大跨度桥梁主梁涡激振动响应的有效途径之一。大比例主梁节段模型（通常为1：15～1：20）几何尺度更大,试验雷诺数更接近实桥值,同时在模型加工制作方面也可更精确地模拟主梁细节。通过一扁平钢箱梁1：20大比例节段模型试验,优化了检查车轨道位置,分析了涡激振动典型现象如振幅、涡振区与阻尼、Scruton数关系,迎角与斯托劳哈数5￡关系,双竖向涡振区等,为节段模型涡振试验结果向实桥拓展提供理论与试验基础。     

乙烯燃烧简化化学动力学模型及其验证

采用“准稳态”方法,从乙烯燃烧的详细化学反应动力学模型出发,建立了包含20个组分和16步总包反应的简化化学动力学模型。为检验动力学模型的有效性,在我国同步辐射实验室燃烧站上开展了乙烯／O2／Ar的层流预混火焰组分测量。应用一维数值方法对实验结果进行了模拟,计算的组分分布和实验测量数据进行了对比。结果表明：简化反应动力学模型能有效地再现详细基元反应模型的反应机理,具有较高精度;但采用乙烯详细化学动力学模型计算结果与实验测量还存在一定的差异,需要进一步改进。     

基于贝叶斯网络的航空公司飞行安全系统评价

开展航空公司的飞行安全系统评价是提高飞行安全运行水平的重要措施。在对国内外相关研究成果进行分析和比较的基础上,结合飞行安全评价中的不确定性特点,利用飞行安全评价指标体系,建立了基于贝叶斯网络的飞行安全系统评价模型。该模型能够有效地处理专家意见一致或不一致的情形,并对系统进行预测及诊断分析。通过对某航空公司飞行安全运行状况的实例评价,结果表明此方法是合理有效的。     

基于目标状态方程的SRM非线性预测控制

提出了一种基于目标状态方程的开关磁阻电机非线性预测控制方法,根据建立开关磁阻电机的非线性数学模型,按照非线性控制理论,定义转矩偏差和速度偏差为目标状态方程。以此状态方程为基础,结合预测控制理论对开关磁阻电机控制系统进行非线性预测控制设计,得到了以转速和转矩为反馈变量的非线性预测控制规律。根据所设计的控制器,通过软件仿真进行了验证。仿真结果表明,采用基于目标状态方程的开关磁阻电机非线性预测控制方法设计的SRM控制系统具有良好的动态和静态性能,对抑制开关磁阻电机转矩脉动有很好的效果。     

基于统一方法架构的软件开发过程模型辅助系统

介绍了基于统一方法架构的软件开发过程模型辅助系统,它是对RUP的裁减和定制,以满足航空电子软件开发的特殊性。还介绍了软件开发过程模型辅助系统在型号项目以及新员工中的应用案例及应用结果。     

航空电子的故障预测与健康管理技术

分析了引发航空电子设备故障的各种因素;详细讨论了航空电子设备全寿命周期内的故障预测与健康管理（PHM）技术,包括故障检测与健康监测、健康信息处理、故障预测和余寿评估;还介绍了基于健康信息综合管理的航空电子PHM系统的设计。